Acetylcysteine is a derivative of the amino acid cysteine. Has a mucolytic effect, it facilitates expectoration due to the direct impact on the rheological properties of sputum.
Action due to the ability to break disulfide bonds mucopolysaccharide chains and cause depolymerization mukoproteidov sputum, which reduces the viscosity of sputum. The drug remains active in the presence of purulent sputum.
Antiokcidantnoe exerts an action based on the ability of its reactive sulfhydryl groups (SH-groups) bind to oxidative radicals and thereby neutralize them.
In addition, acetylcysteine promotes the synthesis of glutathione, an important component of the antioxidative system and chemical detoxification. Antioxidant action acetylcysteine enhances the protection of cells from the damaging effects of free radical oxidation, characteristic of intense inflammatory reaction.
When prophylactic use of acetylcysteine marked decrease in the frequency and severity of exacerbations of bacterial etiology in patients with chronic bronchitis and cystic fibrosis.
Sinusitis, otitis, tracheitis, chronic obstructive pulmonary disease, bronchitis, Cough, Pneumonia, Sinusitis
Respiratory diseases, accompanied by the formation of a viscous sputum:
bronchiectasis, asthma, chronic obstructive pulmonary disease (COPD), bronchiolitis;
Acute and chronic sinusitis, inflammation of the middle ear (otitis media).
gastric ulcer and duodenal ulcer history, bronchial asthma, obstructive bronchitis, liver and / or kidney failure, histamine intolerance (avoid prolonged drug administration, as acetylcysteine affect the metabolism of histamine can cause symptoms of intolerance, such as headache, vasomotor rhinitis, itching), varicose veins of the esophagus, adrenal disease, hypertension.