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What is Calve's Disease?

Description of the disease

Calve's Disease, or Calve's Syndrome, is a rare genetic condition that leads to a disruption in the metabolism of bone tissue.


  • Calve's Disease Type 1
  • Calve's Disease Type 2


  • Bone pain
  • Deformation of the skeleton
  • Mild tendency to fractures


The disease is caused by a mutation in the COL1A1 or COL1A2 genes, which are responsible for the formation of collagen, the main protein of bones.


The diagnosis is made based on clinical manifestations and genetic tests.


Treatment is aimed at improving the patient's quality of life, including the use of pain relievers and physiotherapy.


Since the disease is genetic, there are no specific prevention methods, but genetic counseling can help reduce the risk of passing the disease to offspring.


Treatment is conducted by an orthopedic surgeon or geneticist.

Note: This material is provided for informational purposes only and is not medical advice.