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What are Benign Hyperbilirubinemias?

Description of the disease

Benign hyperbilirubinemias are a group of genetic disorders characterized by elevated levels of bilirubin in the blood, but without pathological changes in the liver or bile ducts.


  • Genetic hyperbilirubinemia type I (Gilbert);
  • Genetic hyperbilirubinemia type II (Dubin-Johnson);
  • Genetic hyperbilirubinemia type III (Crigler-Najjar).


Usually benign hyperbilirubinemias are asymptomatic, although some patients may occasionally experience weakness, nausea, or discomfort in the abdominal area.


The cause of benign hyperbilirubinemias is a disruption of bilirubin metabolism in the body, due to a defect in the genes responsible for its processing.


Diagnosis is based on measuring the level of bilirubin in the blood, as well as genetic testing to identify the specific defect.


Benign hyperbilirubinemias do not require specific treatment, but in some cases symptomatic therapy may be needed to alleviate discomfort.


Since the disease is genetic, there are no specific preventive measures. It is important to undergo regular medical observation and follow the recommendations of doctors.


The diagnosis and treatment of benign hyperbilirubinemias is carried out by a gastroenterologist or geneticist.

Note: This material is provided solely for informational purposes and is not medical advice.