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Fervex without sugar, powder 10 pcs

Fervex without sugar, powder 10 pcs

$21.99

(In stock)

Fervex without sugar, powder 10 pcs


  • Paracetamol has an analgesic and antipyretic effect, which is associated with its effect on the thermoregulation center in the hypothalamus; eliminates headache and other types of pain, reduces fever;

  • Ascorbic acid (vitamin C) is involved in the regulation of redox processes, carbohydrate metabolism, blood clotting, tissue regeneration, the synthesis of GCS, collagen and procollagen; normalizes capillary permeability. It increases the body's resistance, which is associated with the stimulation of the immune system;

  • Pheniramine, a blocker of the H1-histamine receptors, reduces rhinorrhea, nasal congestion, sneezing, tearing, itching and redness of the eyes.

Availability: In stock

$21.99

COMPOSITION

Paracetamol (Paracetamolum) 500 mg; Pheniraminum (Pheniraminum) 25 mg; Ascorbic acid (Acidum ascorbinicum) 200 mg. Excipients: mannitol; anhydrous citric acid; Povidone; anhydrous trimagnitic citrate; aspartame; lemon-rum flavor (antilles)

PHARMACOLOGICAL EFFECT

Paracetamol has an analgesic and antipyretic effect, which is associated with its effect on the thermoregulation center in the hypothalamus; eliminates headache and other types of pain, reduces fever .; Ascorbic acid (vitamin C) is involved in the regulation of redox processes, carbohydrate metabolism, blood clotting, tissue regeneration, the synthesis of GCS, collagen and procollagen; normalizes capillary permeability. It increases the body's resistance, which is associated with the stimulation of the immune system .; Pheniramine, a blocker of the H1-histamine receptors, reduces rhinorrhea, nasal congestion, sneezing, tearing, itching and redness of the eyes.

PHARMACOKINETICS

Paracetamol is rapidly and almost completely absorbed from the gastrointestinal tract. Cmax in plasma is reached in 10-60 minutes after ingestion. Distributed in most body tissues. Gets through a placental barrier, it is allocated with breast milk. At therapeutic concentrations, plasma protein binding is low, but increases with increasing concentration. Subject to primary metabolism in the liver. Excreted mainly in the urine in the form of glucuronides and sulfates. T1 / 2 is from 1 to 3 hours; Pheniramine; Pheniramine Cmax in plasma is reached in approximately 1-2.5 hours. Pheniramine T1 / 2 - 16-19 hours. 70-83% of the dose is eliminated from the body through urine as metabolites or unchanged; Vitamin C. Well absorbed in the digestive tract. Tmax after ingestion - 4 hours. Metabolized mainly in the liver. Excreted by the kidneys, through the intestines, with sweat - unchanged and in the form of metabolites.

INDICATIONS

Infectious and inflammatory diseases (ARVI, influenza), accompanied by high fever, chills and fever, headache, runny nose, nasal congestion, sneezing and muscle pain.

CONTRAINDICATIONS

Hypersensitivity to paracetamol, ascorbic acid,Pheniramine or any other component of the drug; erosive and ulcerative lesions of the gastrointestinal tract (in the acute phase); renal failure; portal hypertension; alcoholism; deficiency of the enzyme glucose-6-phosphate dehydrogenase; children's age (up to 15 years); pregnancy (I and III trimester) and lactation.

USE DURING PREGNANCY AND LACTATION

Contraindicated

DOSAGE AND ADMINISTRATION

Inside, completely dissolved in a glass (200 ml) of warm water (50–60 ° C), immediately drink the resulting solution. It is better to take the drug between meals .; 1 bag 2–3 times a day. The interval between doses of the drug should be at least 4 hours. In patients with impaired liver or kidney function and in elderly patients, the interval between doses of the drug should be at least 8 hours; The duration of treatment without consulting a doctor is not more than 5 days when prescribed as an anesthetic and no more than 3 days as an antipyretic.

SIDE EFFECTS

The drugs are well tolerated in the recommended doses .; Nausea, pain in the epigastric region, allergic reactions (skin rash, itching, urticaria, angioedema) .; Rarely - blood disorders (anemia, thrombocytopenia, methemoglobinemia), dry mouth, accommodation paresis, urinary retention, drowsiness. With prolonged use (in doses significantly higher than recommended) increases the likelihood of impaired liver and kidney function, control of the peripheral blood picture is necessary. All side effects of the drug should be reported to the doctor. If adverse reactions occur, stop taking the drug and consult a doctor.

OVERDOSE

Symptoms of an overdose due to paracetamol: pallor of the skin, loss of appetite, nausea, vomiting; hepatonecrosis (severity of necrosis due to intoxication depends on the degree of overdose). Toxic effects in adults are possible after taking more than 10–15 g of paracetamol: increased activity of hepatic transaminases, an increase in PV (12–48 hours after ingestion); A detailed clinical picture of liver damage occurs after 1–6 days. Rarely, liver failure develops with lightning speed and may be complicated by renal failure (tubular necrosis) .; Treatment: in the first 6 hours after an overdose, gastric lavage, the introduction of SH-group donators and the precursors of glutathione-methionine synthesis 8–9 hours after the overdose, and N-acetylcysteine ​​12 hours laterThe need for additional therapeutic measures (the further introduction of methionine, in / in the introduction of N-acetylcysteine) is determined by the concentration of paracetamol in the blood, as well as the time that has passed since taking it.

INTERACTION WITH OTHER DRUGS

Ethanol enhances the sedative effect of antihistamine drugs .; Antidepressants, anti-parkinsonian drugs, antipsychotics (phenothiazine derivatives) increase the risk of side effects (urinary retention, dry mouth, constipation). GCS increases the risk of developing glaucoma .; Inducers of microsomal oxidation in the liver (phenytoin, ethanol, barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants) increase the production of hydroxylated active metabolites, which makes it possible to develop severe intoxications with small overdose. Ethanol contributes to the development of acute pancreatitis .; Inhibitors of microsomal oxidation (including cimetidine) reduce the risk of hepatotoxic action. Paracetamol reduces the effectiveness of uricosuric drugs.

SPECIAL INSTRUCTIONS

Perhaps the distortion of indicators of laboratory tests in the quantitative determination of the concentration of uric acid and glucose in plasma. In order to avoid toxic damage to the liver, paracetamol should not be combined with the intake of alcoholic beverages, as well as be taken by persons prone to chronic alcohol consumption. The risk of liver damage increases in patients with alcoholic hepatosis .; Additionally, for Fervex lemon without sugar: the drug does not contain sugar and can be used by patients suffering from diabetes.
Additional Information
SKU m130
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