Combined medicinal product. Paracetamol is an analgesic-antipyretic. It possesses analgesic, antipyretic, and weak anti-inflammatory effects. Its mechanism of action is associated with the inhibition of prostaglandin synthesis, predominantly affecting the thermoregulation center in the hypothalamus. The lack of influence on prostaglandin synthesis in peripheral tissues accounts for its absence of negative effects on water-electrolyte balance (sodium and water retention) and the gastrointestinal mucosa. Caffeine stimulates the psychomotor centers of the brain, has a stimulating effect, enhances the effects of analgesics, alleviates drowsiness and fatigue, increases physical and mental performance.
The medicinal product exhibits a calming effect on the central nervous system and also has a moderate reflex vasodilating (coronary) effect by reflex irritation of sensitive nerve ("cold") receptors of the oral mucosa. Stimulation of the receptors is accompanied by the release of endorphins, enkephalins, dynorphins, and other peptides, histamine, kinins, which play an important role in reducing pain sensitivity, normalizing vascular permeability, and regulating other important mechanisms of cardiovascular and nervous system function.
Pharmacokinetics:
When administered sublingually, Corvalment® is absorbed from the mucous membrane of the oral cavity. The therapeutic effect occurs approximately 5 minutes after administration.
After absorption, it undergoes biotransformation in the liver and is excreted in the urine as glucuronides.
Indications: Mild angina attacks; Motion sickness; Hysteria; Neurosis; Headaches associated with the use of nitrates.
A natural remedy, which contains extracts from Korean ginseng, Siberian ginseng and guarana. This product is a tonic stimulantand adaptogen, and therefore: