Combined drug, the action of which is due to its constituent components.
Ibuprofen It has an anti-inflammatory effect and does not belong to the steroid group. It has the ability to inhibit cyclooxygenase, which is responsible for the metabolism of arachidonic acid, a precursor of prostaglandin. In the body, these enzymes act as mediators of pain, inflammation and fever due to the ability to excite pain receptors, dilate vessels, increase cell permeability, which leads to tissue damage and the formation of inflammation. In violation of the synthesis of prostaglandins under the influence of the active substance is achieved anti-inflammatory, antipyretic and analgesic effect.
Paracetamol. Indiscriminately blocks COX, mainly in the central nervous system, has little effect on the water-salt metabolism and the mucous membrane of the gastrointestinal tract (GIT). It has analgesic and antipyretic effects. In inflamed tissues, peroxidases neutralize the effect of paracetamol on COX 1 and 2, which explains the low anti-inflammatory effect.
The effectiveness of the combined drug is several times higher than the components present in it separately.
Indications for use of the drug (from which Ibuclin Junior tablets are used for symptomatic treatment):
bouts of neuralgia;
pains of varying intensity in the back;
pain resulting from dislocations, sprains, fractures, severe bruises;
joint pain, pain resulting from diseases of the musculoskeletal system;
feverish conditions, including those resulting from a cold or flu;
postoperative or post-traumatic pain syndrome.
From what Ibuclin Junior is used in the treatment of children, the pediatrician will explain in more detail. You should know exactly what the drug is used for and how it helps, because it can only reduce pain and inflammation during the period of use. On the progress of the disease in general, its use is not affected.
A sensible person will never drink medicine without reading the list of contraindications. Moms need to be a hundred times more careful when choosing preparations for babies. Let's see what the instructions to Ibuclin Junior say about contraindications, how many “pitfalls” there are in it, and since how many years it has been resolved.
The drug is not recommended to receive:
children under 3 years old, pregnant and lactating;
in case of optic nerve disease;
with bronchial asthma;
in the presence of ulcerative and inflammatory processes in the digestive system, gastric and intestinal bleeding;
with renal and hepatic insufficiency;
in case of individual intolerance to any component of the tool.
In the first and second trimesters of pregnancy, use is possible only as prescribed by a doctor in cases where the potential benefit outweighs the possible risk to the mother and the potential risk to the fetus. The use of this combination in the third trimester of pregnancy is contraindicated.
If necessary, use during lactation should stop breastfeeding.
The instructions for use indicated that Ibuclin Junior is taken orally, after dissolving the tablet in 5 ml (a teaspoon) of water. The interval between taking pills should be at least 4 hours, and in case of impaired renal or liver function, at least 8 hours. The daily dose is recommended to be divided into 2-3 doses.
The recommended daily dosing of Ibuclin Junior for children:
3–6 years with a body weight of 13–20 kg: 3 tablets;
6–12 years old with a body weight of 20–40 kg: up to 6 tablets.
The drug should not be taken more than 5 days as an anesthetic and more than 3 days as a febrifuge without medical supervision.
Possible side effects that you may encounter when taking Ibuclin Junior:
From the side of the central nervous system: most often - insomnia, irritability, dizziness and headache; less often - a violation of the organs of vision.
On the part of the digestive system: more often - nausea and vomiting, bitterness and metallic taste in the company; less often - lesions of the mucous membrane of the digestive organs of an erosive-ulcerative nature.
On the part of the immune system: more often allergic reactions such as urticaria, skin rash; less often - angioedema.
Urinary system - prolonged use disrupts the normal functioning of the kidneys and other organs of the urinary system.
In therapeutic doses, the drug is generally well tolerated. If you experience side effects, you should stop taking the drug and consult a doctor.
Symptoms of Ibuclin Junior overdose: abdominal pain, nausea, vomiting, diarrhea, anorexia, epigastric pain, lethargy, drowsiness, depression, headache, tinnitus, metabolic acidosis, acute renal failure, coma, decreased blood pressure (BP), bradycardia, tachycardia, atrial fibrillation, respiratory arrest.
Recommended treatment: gastric lavage (within the first hour after ingestion), administration of activated carbon, forced diuresis, alkaline drinking, symptomatic therapy aimed at correcting blood pressure and the general condition of the patient. Other methods of treatment are determined individually by the attending physician and depend on the concentration of ibuprofen and paracetamol in the body.
Ibuprofen can mask the objective signs of infectious diseases, therefore, ibuprofen therapy in patients with infectious diseases should be administered with caution.
The feasibility of using the drug as an antipyretic is solved in each case, depending on the severity, nature and tolerance of febrile syndrome.
With the simultaneous use of anticoagulants of indirect action, it is necessary to monitor indicators of blood coagulation.
Co-administration of Ibuclin Junior with other NSAIDs should be avoided.
To reduce the risk of adverse events from the gastrointestinal tract, use the minimum effective dose of the shortest possible course.
The drug may distort the results of laboratory tests in the quantitative determination of glucose, uric acid in serum, 17-ketosteroids (the drug must be removed 48 hours before the study).
With prolonged (more than 5 days) intake of the drug, control of peripheral blood and the functional state of the liver is necessary.
Caffeine enhances the analgesic effect of ibuprofen.
Antacids and colestyramine reduce the absorption of the combination of ibuprofen + paracetamol.
Combination with ethanol, GCS increases the risk of erosive and ulcerative lesions of the gastrointestinal tract.
Increases blood concentration of digoxin, lithium preparations and methotrexate.
With the simultaneous use of this combination with cyclosporine and gold preparations increases nephrotoxicity.
This combination enhances the hypoglycemic effect of insulin and oral hypoglycemic drugs.
Weakens the effects of antihypertensive drugs and diuretics (by inhibiting the synthesis of renal prostaglandins).
Myelotoxic drugs contribute to the hematotoxicity of the ibuprofen + paracetamol combination.
With the simultaneous use of this combination with cefamundol, cefoperazone, cefotetan, valproic acid, plicamycin, the incidence of hypoprothrombinemia increases.
Ibuprofen enhances the effect of direct (heparin) and indirect (coumarin and indandion derivatives) anticoagulants, thrombolytic agents (alteplase, anistreplaza, streptokinase, urokinase), antiplatelet agents, colchicine - the risk of hemorrhagic complications increases.
With simultaneous use with acetylsalicylic acid, ibuprofen reduces its anti-inflammatory and antiplatelet effect (it is possible to increase the incidence of acute coronary insufficiency in patients receiving small doses of acetylsalicylic acid as an antiplatelet agent, after the start of administration).